Negative Emotions and Gene Expression

By: Margaret W. Lavigne


For some people, gratitude just doesn’t come as easy. The quality and frequency of expressions of gratitude toward our loved ones decidedly affect our ability to practice gratitude.


Studies found the brains of people with the “less grateful” version are being less sensitive to positive life events and super-sensitive to negative life events. Gradually, these individuals may develop a habit of neglecting the positive aspects of life events and become more sensitive to misfortunes, resulting in decreased ability to practice gratitude and forgiveness. (Reference: A study conducted by Sara Algoe and colleagues).


Negative Thoughts Proved to Change Your Gene Expression

Our body interprets all negative emotions as epigenetic stress signals. This partly explains why unhappy depressed people have weakened immune systems and more susceptible to infections for sure. Patterns of gene expression in the brains of unhappy individuals differs from happier individuals.[1]

image source: The brain governs our appetites, sleep and emotions, but new research shows that in the brains of people with depression, the level of the gene activity inside their brain cells may be broken. The findings come from scientists from the University of Michigan Medical School and other institutions.


Brain’s Reaction to Depression 

Researches found that depression and elevated cortisol correlate with changes in gene expression in the limbic system[1] , which is central to our stress response.


[1] limbic system is a complex system of nerves and networks in the brain, which is in charge of our instinct and mood. It controls our basic emotions, ranging from fear, pleasure to anger. Further, the limbic system drives hunger and sex desires.


Chronic Depression &  Immune Cell Aging

Emotions turn genes on and off. Studies have verified the fact that  chronic depression accelerates immune cell aging. There’s a strong link between depression and trauma.  In other words, old mental wounds accelerates early aging. Indeed, studies found that people who  live with major depressive disorder are biologically older than people without depression.


Again, depression leads to chronic illness and premature aging. Negative emotions includes suppressed anger and unshakable sorrow. Negative emotions guarantees a higher blood sugar level. Anxiety and fear potentially lead to blood clotting and heart disease. 


The Benefits of Suffering: Training and Growing 

Suffering teaches us to be humble and compassionate. It’s comforting to know that we can only witness unconditional love in the hard times. Be hopeful, tender, humble and righteous in any circumstances, and life will get better. 


  1. What You’re Feeling Influences Your Genes
  2. impact of positive emotion on DNA 
  3. Positive emotion-specific changes in the gene expression profile of tickled rats.
  4. Epigenetic Genes and Emotional Reactivity to Daily Life Events: A Multi-Step Gene-Environment Interaction Study
  5. Trauma and Gene Expression: Understanding the Connections
  6. Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder
  7. Body clocks of depressed people altered at cell level, researchers show
  8. Effects of gratitude meditation on neural network functional connectivity and brain-heart coupling

  9. Gene Expression Overlaps Among Psychiatric Disorders

  10. Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder
  11. A Gene Co-expression Network-based Analysis of Multiple Brain Tissues Reveals Novel Genes and Molecular Pathways Underlying Major Depression
  12. Writing about gratitude increases emotion-regulation efficacy


Anxiety Disorder and Unshakable Fear 

Some people are gripped by unshakable anxieties in normal everyday situations and suffer from various dramatic symptoms, such as palpitations, fainting and blind panic.


Social Phobia and Self-Isolation 
Some people are dread of becoming the center of attention in a group. To avoid possible attack, humiliation or embarrassment, the sufferers shy away from human contact by isolating themselves at home.


The medical researchers in Bonn found patients who suffer from a severe form of panic disorder showed a much more highly activated coagulation system than the healthy control group. The coagulation system goes out of balance as the coagulation tendency rises and the imbalance potentially lead to blockage of a coronary artery. That’s why patients with anxiety disorders have a statistically higher risk of dying from heart disease or heart attack.

Reduce Stress Level: Practice Gratitude
Do not underestimate the effects of gratitude and resentment on our mental well-being. Positive emotion, such as gratitude, is known to reduce stress levels. People with high life satisfaction show greater neural connectivity than people with low life satisfaction. That’s why gratitude has been associated with a lower risk for psychiatric disorders.


Hatred, blaming and resentment toward other people is highly linked to dissatisfaction in life, which potentially lead to poorer emotional health.







Margaret W. Lavigne 司馬儀

There’s a strong link between imperfection, unconditional love and posttraumatic growth. In truth, we can only witness unconditional love in the hard times. If you believe in luck or miracles, be aware of the seven deadly sins and the seven heavenly virtues. According to the Bible, no one will be exempt from life challenges, including the chosen ones (1 Peter 1:3-9). God expects us to stay hopeful and “rejoice in our sufferings,” because “trials of various kinds” are training to make us “perfect and complete” (Romans 5:3-6, James 1:1-27). It’s comforting to know that “God promises to make something good out of the storm” (Roman 8: 28). We fall and we learn. As we learn to humble ourselves, life gets better. The connection between the brain and stomach is bidirectional. Excessive sugar intake sabotages our immune system that 70% to 80% of our immunity hinges on our gut health. Memory loss and cognitive impairment are common symptoms of Alzheimer’s disease, all of which are highly connected to type 2 diabetes. Early signs of type 2 diabetes include chronic fatigue, irritability, frequent urination, vision problems and slow wound healing. Depression is prevalent in people with diabetes due to the fact that diabetes causes “structural changes in the brain.” It’s worth noting that muscle-building helps regulate blood sugar levels. There is growing evidence that high blood sugar leads to reduced muscle mass. Beyond that, there’s a strong link between sleep deprivation and emotional weakness Be aware of the power of tenderness, humility and subconscious mind. Generally, negative emotions root in the inability to forgive, vanity or pride. People suffer from suppressed anger. God is watching our every move. God sees through our motives. Mental health crisis is sweeping on a global scale because the core value of capitalism is incompatible with what human truly needs. Money cannot purchase inner peace nor unconditional love. Wealth incurs fair-weather friends, frenemies and snobs. I would say, inner peace is the utmost blessing from God. Trauma is highly linked to chronic fatigue and chronic illness. Take time to deal with your old mental wounds. 這裡不是天堂,我們必須勇敢!這輩子身體顧好了,你就賺到四百萬+++。人生,除了身體健康以外的事都是小事,而生病只是提醒不是懲罰,因為無常是:一個健康的人一出門就沒有再回家了,連道別的機會和準備都沒有。人們錯過的都是最悲傷最真實的故事!因為多數人可以分享的都無關緊要的痛或路人皆知的痛。佛教用因果論概括一切,而聖經主張人生必有難題(包括選民),但好好表現,災難背後會有禮物。如果你以為誰的人生很輕鬆,肯定是你跟對方不熟。脖子控管自律神經!肩頸僵硬,「自律神經」就會被受到壓迫!自律神經失調引發的症狀包括頭痛、暈眩、焦慮、失眠、倦怠、口渴、耳鳴,甚至憂鬱等症狀。自律神經失調了,血液的品質也會跟著惡化!解法:甩手操。建議多按壓頭皮、耳朵和手上的穴道。腸胃健康和大腦健康息息相關,國外大力探討久坐對身體的傷害!健康建議:天芢無糖抹茶搭配芝麻和牛奶X 無糖豆漿X鹼性飲食X淋巴按摩X提高肌肉量(控制血糖的關鍵,糖尿病是可逆轉的)。鈣是解痛劑(看牙科前)。維生素E主修復,可避免留疤。高壓容易緊張族群可多攝取維生素B和鈣的食物。一夜白頭是心理影響身體的鐵證,勿低估負面情緒對身體的傷害,包括生悶氣或憂愁。詳情請參看網站醫療專欄。壞脾氣一定有理由,可能是高血糖或創傷症候群或高壓族群,而壞情緒會把幸運福氣和天使嚇跑。禍福相依,好消息可能會成為頭痛點,壞消息可能成為跳板!不屬於自己的只會逗留,不會久留,勿強求。引用小說《推理愛》:「判斷一個人愛不愛她很難,但判斷一個人珍不珍惜她卻很簡單。」「柔和」「謙卑」與「歸零」的力量。自信缺氧,就用力學習。不自律就無法成為更好的自己,不自律就無法肯定自己!提醒自己做該做的而不是想做的。預防改善糖尿病推薦食材:洋蔥、無糖抹茶、咖哩及酪梨。理財時代,從照顧好自己的健康開始。遠離乳癌,醫師呼籲不要使用塑膠袋裝熱食!國外研究證實:阿茲海默症患者「禁糖」便可望痊癒!人們低估了「糖過量」及「過食」對身體的破壞力。咖啡和巧克力的好被過度放大.精神不濟喝咖啡恐消耗維生素B。聖經說了,說過的每句話都會被記錄在一本書裡!好壞都被記錄了,所以聖經主張人們不可記他人的過錯。最佳午睡時間是20分鐘和90分鐘。以上,互相督促。生命線協談專線:1995 安心專線:1925 張老師專線:1980 自殺防治諮詢安心專線:0800-788995 聯繫司馬儀(譬如跨界合作):Gmail: 




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